KETOGENIC DIET / NUTRITIONAL KETOSIS / KETONES

This area has now been studied for over 100 years.

ARTICLES / VIDEOS

Dr Andra Campitelli – Naturopathic Doctor, Educator & Nutraceutical Specialist
Dr Heather Cardin –  Doctorate of Chiropractic from Cleveland Chiropractic College

Cliff Harvey – Naturopath, Nutritionist, Author, Speaker and Researcher based on Auckland

ARTICLES / VIDEOS
1/ The official Pruvit Research Page with key articles of interest
2/ Beneficial effects of ketogenic diets for cancer patients
3/ The Ketogenic2Diet and Autism
4/ Intermittent Fasting and Lifespan
5/ The Conundrum of Cholesterol & Ketones
6/ Doctor Explains What Happens To The Human Body When It Goes Into Ketosis
7/ Ketosis and Traumatic Brain Injury: A Former Athlete’s Perspective
8/ It’s getting clearer — the diet-cancer connection points to sugar and carbs
9/ Reversing Type 2 Diabetes with Nutritional Ketosis
10/ How Ketogenic Diets Curb Inflammation
11/ Starving cancer: Dominic D’Agostino at TEDxTampaBay (Video)
12/ Webinar with Cliff Harvey (ND) and Joe Rogister (Video)
13/ Neuroscience Reveals What Fasting Does To The Brain (And Why Big Pharma and the Food Industry Won’t Study It) (Video)

JOURNALS
1/ The Effects of Ketogenic Dieting on Body Composition, Strength, Power, and Hormonal Profiles in Resistance Training Males
2/ A modified ketogenic gluten-free diet with MCT improves behavior in children with autism spectrum disorder
3/ Anti-seizure effects of nutritional ketosis as a tool for treating Alzheimer’s disease (different name)
4/ Efficacy of Metabolically Supported Chemotherapy Combined with Ketogenic Diet, Hyperthermia, and Hyperbaric Oxygen Therapy for Stage IV Triple-Negative Breast Cancer
5/ Twelve-month outcomes of a randomized trial of a moderate-carbohydrate versus very low-carbohydrate diet in overweight adults with type 2 diabetes mellitus or prediabetes
6/ Ketone Bodies as Anti-Seizure Agents
7/ Beta-hydroxybutyrate, an endogenic NLRP3 inflammasome inhibitor, attenuates stress-induced behavioral and inflammatory responses
8/ Ketogenic diet versus gluten free casein free diet in autistic children: a case-control study
9/ Ketogenic diet in migraine: rationale, findings and perspectives
10/ Pleiotropic effects of nutritional ketosis: Conceptual framework for keto-adaptation as a breast cancer therapy
11/ Twelve-month outcomes of a randomized trial of a moderate-carbohydrate versus very low-carbohydrate diet in overweight adults with type 2 diabetes mellitus or prediabetes
12/ Targeting the Warburg effect for cancer treatment: Ketogenic diets for management of glioma
13/ The promising potential role of ketones in inflammatory dermatologic disease: a new frontier in treatment research
14/ Diet-Induced Ketosis Protects Against Focal Cerebral Ischemia in Mouse
15/ High glucose levels promote the proliferation of breast cancer cells through GTPases
16/ Intermittent Fasting Protects against Alzheimer’s Disease Possible through Restoring Aquaporin-4 Polarity
17/ When less may be more: calorie restriction and response to cancer therapy
18/ Nutritional Ketosis Affects Metabolism and Behavior in Sprague-Dawley Rats in Both Control and Chronic Stress Environments
19/ Carbohydrate-Restriction with High-Intensity Interval Training: An Optimal Combination for Treating Metabolic Diseases?
20/ Ketogenic diet versus gluten free casein free diet in autistic children: a case-control study
21/ Associations of fats and carbohydrate intake with cardiovascular disease and mortality in 18 countries from five continents (PURE): a prospective cohort study
22/ The ketogenic diet as a treatment paradigm for diverse neurological disorders
23/ 10 patients, 10 years – Long term follow-up of cardiovascular risk factors in Glut1 deficiency treated with ketogenic diet therapies: A prospective, multicenter case series
24/ Metabolic characteristics of keto-adapted ultra-endurance runners
25/ Hepatic Ketogenesis Induced by Middle Cerebral Artery Occlusion in Mice
26/ Role of ketogenic metabolic therapy in malignant glioma: A systematic review
27/ Do ketogenic diets really suppress appetite? A systematic review and meta-analysis
28/ The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease
29/ Targeting energy metabolism in brain cancer: review and hypothesis
30/ beta-Hydroxybutyrate decreases adenosine triphosphate degradation products in human subjects
31/ Management of Glioblastoma Multiforme in a Patient Treated With Ketogenic Metabolic Therapy and Modified Standard of Care: A 24-Month Follow-Up
32/ Caffeine intake increases plasma ketones: an acute metabolic study in humans

EXOGENOUS KETONES

This is the exciting new area of study! This section will grow over the coming years as more studies are completed, especially on humans.

ARTICLES / VIDEOS
1/ Dietary Supplement With Ketones May Mitigate Migraine Attacks
2/ Exogenous Ketones: What They Are, Benefits of Use and How They Work
3/ Webinar with Cliff Harvey (ND) and Joe Rogister (Video)
4/ Exogenous ketones, how the hell did I get here, and who are these people?
5/ A Deep Dive Into Ketosis: How Navy Seals, Extreme Athletes & Busy Executives Can Enhance Physical and Mental Performance With The Secret Weapon of Ketone Fuel
6/ Four New, Cutting-Edge Ways To Easily Shift Your Body Into Fat-Burning Mode & Ketosis

JOURNALS
1/ On the Metabolism of Exogenous Ketones in Humans
2/ Anxiolytic Effect of Exogenous Ketone Supplementation Is Abolished by Adenosine A1 Receptor Inhibition in Wistar Albino Glaxo/Rijswijk Rats
3/ Anticonvulsant effect of exogenous β-hydroxybutyrate on kainic acid-induced epilepsy
4/ The glucose-lowering effects of exogenous ketones: is there therapeutic potential?
5/ Prior ingestion of exogenous ketone monoester attenuates the glycaemic response to an oral glucose tolerance test in healthy young individuals (Ketone Esters)
6/ A Ketone Ester Drink Lowers Human Ghrelin and Appetite  (Ketone Esters)
7/ β-hydroxybutyrate alleviates depressive behaviors in mice possibly by increasing the histone3-lysine9-β-hydroxybutyrylation
8/ D-β-hydroxybutyrate promotes functional recovery and relieves pain hypersensitivity in mice with spinal cord injury
9/ The promising potential role of ketones in inflammatory dermatologic disease: a new frontier in treatment research
10/ Metabolism of ketone bodies during exercise and training: physiological basis for exogenous supplementation (Ketone Esters)
11/ Oral β-hydroxybutyrate increases ketonemia, decreases visceral adipocyte volume and improves serum lipid profile in Wistar rats
12/ Effects of exogenous ketone supplementation on blood ketone, glucose, triglyceride, and lipoprotein levels in Sprague-Dawley rats
13/ Protective effects of exogenous β-hydroxybutyrate on paraquat toxicity in rat kidney
14/ Metabolic effects of exogenous ketone supplementation – an alternative or adjuvant to the ketogenic diet as a cancer therapy?
15/ Ketone Body Infusion With 3‐Hydroxybutyrate Reduces Myocardial Glucose Uptake and Increases Blood Flow in Humans: A Positron Emission Tomography Study
16/ Intake of a Ketone Ester Drink during Recovery from Exercise Promotes mTORC1 Signaling but Not Glycogen Resynthesis in Human Muscle(Ketone Esters)
17/ Ketone supplementation decreases tumor cell viability and prolongs survival of mice with metastatic cancer (Ketone Esters)
18/ Therapeutic ketosis with ketone ester delays central nervous system oxygen toxicity seizures in rats (Ketone Esters)
19/ Non-Toxic Metabolic Management of Metastatic Cancer in VM Mice: Novel Combination of Ketogenic Diet, Ketone Supplementation, and Hyperbaric Oxygen Therapy (Ketone Esters)
20/ Effects of beta-hydroxybutyrate on cognition in memory-impaired adults (MCT)